狀態 退休教師
姓名 李宣書
職稱 教授
授課領域 Stem Cell Biology Regenerative Medicine Seminar
研究專長 肝臟醫學 / 肝臟生理病理學 / 肝臟幹細胞 / 組織工程
年度 論文名稱
2016 Huan YJ, Chen P, Lee CY, Yang SY, Lin MT, Lee HS*, Wu YM*. , Protection against acetaminophen-induced acute liver failure by omentum adipose tissue derived stem cells through the mediation of Nrf2 and cytochrome P450 expression.(in press)., J Biomed Sci , 2016
2016 Wu YM, Huang YJ, Chen P, Hsu YC, Lin SW, Lai H*, Lee HS*. , Hepatocyte-like cells derived from mouse induced pluripotent stem cells produce functional coagulation factor IX in a hemophilia B mouse model.(in press)., Cell Transplan, 2016
2015 Chang CC, Lin WC, Pai LM, Lee HS, Wu SC, Ding ST, Liu JL, Sung LY. , Cytoophidium assembly reflects upregulation of IMPDH activity., J Cell Sci, vol. 128, pp. 3550-3555, 2015
2015 Chen YB, Lan YW, Chen LG, Huang TT, Choo KB, Cheng WT, Lee HS*, Chong KY*., Mesenchymal stem cell-based HSP70 promoter-driven VEGFA induction by resveratrol alleviates elastase-induced emphysema in a mouse model., Cell Stress Chaperons 2015; 20:979-989., vol. 20, pp. 979-989, 2015
2015 Chen YB, Lan YW, Hung TH, Chen LG, Choo HB, Cheng WTK, Lee HS*, Chong KY*., Mesenchymal stem cell-based HSP70 promoter-driven VEGFA induction by resveratrol promotes angiogenesis in a mouse model. , Cell Stress Chaperons, vol. 20, pp. 643-652, 2015
2015 Wang MH, Chien CY, Wang PY, Yu HM, Lee HS*, Lin WJ*. , The specificity and accuracy of 111In-hexavalent lactoside in estimating liver reserve and its threshold value for mortality in mice., J Hepatol , vol. 63, pp. 370-377, 2015
2015 Wang MH, Chien CY, Wang PY, Yu HM, Lee HS*, Lin WJ*. , The specificity and accuracy of 111In-hexavalent lactoside in estimating liver reserve and its threshold value for mortality in mice., J Hepatol , vol. 63, pp. 370-377, 2015
2015 Huang YW, Chiu CC, Liang JD, Chiou LL, Huang GT, Yu MJ*, Lee HS*., Brain isoform glycogen phosphorylase as a novel hepatic progenitor cell marker. , PLoS ONE, vol. 10, pp. e0122528-, 2015
2015 Huang TY, Wu CH, Wang MH, Chen BS, Chiou LL, Lee HS*. , Cooperative regulation of substrate stiffness and extracellular matrix proteins in skin wound healing of axolotls. , BioMed Res Int , pp. 712546-, 2015
2015 Wu CH, Huang TY, Chen BS, Chiou LL, Lee HS*. , Long-duration muscle dedifferentiation during limb regeneration in axolotls. , PLoS ONE , pp. e0116068.-, 2015
2015 Lin CJ, Kang N, Lee JY, Lee HS*, Dong CY*., Visualizing and quantifying difference in cytoplasmic and nuclear metabolism in the hepatobiliary system in vivo., J Biomed Opt , vol. 20, pp. 016020-, 2015
2014 Chiang TS, Yang KC, Wu YM, Lai HS, Jiang CC, Chiou LL, Lee KL, Huang GT*, Lee HS*. , Higher expression of cytochrome P450 3A4 in human mesenchymal and adipose-derived stem cells than in dermal fibroblasts: With emphasis on the correlation with basal pregnane X receptor expression. , Process Biochem, vol. 49, pp. 1983-1989, 2014
2014 Kao TH, Liao HF, Wolf D, Tai KY, Chuang CY, Lee HS, Kuo HC, Hata K, Zhang X, Cheng X, Goff SP, Ooi SK, Bestor TH, Lin SP. , Ectopic DNMT3L triggers assembly of a repressive complex for retroviral silencing in somatic cells., J Virol, vol. 88, pp. 10680-10695, 2014
2014 Chen BB, Hsu CY, Yu CW, Kao JH, Lee HS, Liang PC, Wei SY, Hwang RM, Shih TT., Hepatic necro-inflammation and elevated liver enzymes: evaluation with MRI perfusion imaging with gadoxetic acid in chronic hepatitis patients. , Clin Radiol , vol. 69, pp. 473-480, 2014
2014 Fan FY, Chiu CC, Tseng CL, Lee HS, Pan YN, Yang KC., Glycosaminoglycan/chitosan hydrogel for matrix-associated autologous chondrocyte implantation: an in vitro study., J Med Biol Eng 2014;34:211-217., vol. 34, pp. 211-217, 2014
2014 Lin YH, Hwang RM, Chen BB, Hsu CY, Yu CW, Kao JH, Lee HS, Liang PC, Wei SY, Shih TT., Vascular and hepatic enhancements at MRI: comparison of hepatobiliary and traditional extracellular contrast agents in the same subjects. , Clin Imag 2014;38:287-291., vol. 38, pp. 287-291, 2014
2014 Chiang TS, Yang KC, Chiou LL, Huang GT*, Lee HS*., Enhancement of CYP3A4 activity in Hep G2 cells by lentiviral transfection of hepatocyte nuclear factor-1 alpha. , PLoS ONE , vol. 9, pp. e94885.-, 2014
2013 Yang KC, Wu CC, Yang SH, Chiu CC, Sumi S, Lee HS*, Investigating the suspension culture on aggregation and function of mouse pancreatic β-cells., 期刊名, vol. 卷數, 期數, Jan. 2013
2013 Lin YH, Chang HM, Chang FP, Shen CR, Lin CL, Mao WY, Lin CC, Lee HS, Shen CN., Protoporphyrin IX accumulation disrupts mitochondrial dynamics and function in ABCG2-deficient hepatocytes. , FEBS Lett 2013;587:3202-3209., vol. 587, pp. 3202-3209, 2013
2013 Wu CH, Tsai MH, Ho CC, Chen CY*, Lee HS*., De novo transcriptome sequencing of axolotl blastema for identification of differentially expressed genes during limb regeneration. , BMC Genomics 2013;14:434., vol. 14, pp. 434-, 2013
2012 Hung GD, Li PC, Lee HS, Chang HM, Chien CT, Lee KL., Green tea extract supplementation ameliorates CCl(4)-induced hepatic oxidative stress, fibrosis, and acute-phase protein expression in rat. , J Formos Med Assoc, vol. 111, pp. 550-559, 2012
2012 Chen BB, Hsu CY, Yu CW, Wei SY, Kao JH, Lee HS, Shih TT. , Clinical and histologic implications of delayed hepatobiliary enhancement on magnetic resonance imaging with gadolinium ethoxybenzyl diethylenetriaminepentaacetic acid. , Invest Radiol, vol. 47, pp. 649-655, 2012
2012 Chiang TS, Yang KC, Zheng SK, Chiou LL, Hsu WM, Lin FH, Huang GT*, Lee HS*., The prediction of drug metabolism using scaffold-mediated enhancement of the induced cytochrome P450 activities in fibroblasts by hepatic transcriptional regulators. , Biomaterials, vol. 33, pp. 5187-5197, 2012
2012 Cheng SH, Li FC, Souris JS, Yang CS, Tseng FG, Lee HS, Chen CT, Dong CY, Lo LW., Visualizing dynamics of sub-hepatic distribution of nanoparticles using intravital multiphoton fluorescence microscopy., ACS Nano, vol. 6, pp. 4122-4131, 2012
2012 Liang JD, Chen CH, Hsu SJ, Sheu JC, Yang PM, Lee HS, Lee CZ, Huang GT. , Hepatocellular carcinoma with duodenal invasion and metastasis. , J Gastroenterol Hepatol , vol. 27, pp. 677-683, 2012
2012 Chen BB, Hsu CY, Yu CW, Wei SY, Kao JH, Lee HS, Shih TT., Dynamic contrast-enhanced magnetic resonance imaging with Gd-EOB-DTPA for the evaluation of liver fibrosis in chronic hepatitis patients. , Eur Radiol., vol. 22, pp. 171-180, 2012
2011 Yang KC, Qi Z, Yanai G, Shirouza Y, Lu DH, Lee HS*, Sumi S*., Cell coupling regulates Ins1, Pdx1 and MafA to promote insulin secretion in mouse pancreatic beta cells. , Process Biochem, vol. 46, pp. 1853-1860, 2011
2011 Li FC, Huang GT, Lin CJ, Wang SS, Sun TL, Lo SY, Lo W, Chiou LL, Dong CY*, Lee HS*., Apical membrane rupture and backward bile flooding in acetaminophen-induced hepatocyte necrosis. , Cell Death Dis , vol. 2, pp. e183-, 2011
2009 Lin CC, Liang HP, Lee HS, Huang GT, Yang PM, Ho MC, Lee PH, Tsang YM, Chen DS, Sheu JC, Chen CH., Clinical manifestations and survival of hepatocellular carcinoma patients with peritoneal metastasis., J Gastroenterol Hepatol, pp. 815-820, 2009
2009 Li WJ, Chiang H, Kuo TF, Lee HS, Jiang CC, Tuan RS., Evaluation of articular cartilage repair using biodegradable nanofibrous scaffolds in a swine model: a pilot study., J Tissue Eng Regen Med., pp. 1-10, 2009
2009 Li FC, Liu Y, Huang GT, Chiou LL, Liang JH, Dong CY, Lee HS (通訊作者)*., In vivo dynamic metabolic imaging of obstructive cholestasis in mice., Am J Physiol- Gastrointest Liver Physiol, pp. 1091-1097, 2009
2009 Lin BR, Yu CJ, Chen WC, Lee HS, Chang HM, Lee YC, Chien CT and Chen CF., Green tea extract supplement reduces D-galactosamine-induced acute liver injury by inhibition of apoptotic and proinflammatory signaling., J Biomed Sci, pp. 16-35, 2009
2009 Tien YW, Wu YM, Lin WC, Lee HS, Lee PH., Pancreatic carcinoma cells stimulate proliferation and matrix synthesis of hepatic stellate cells., J Hepatol, pp. 307-314, 2009
2009 Chiu CC, Huang YW, Chou SH, Huang GT, Chiou LL, Lee HS, Generation of a monoclonal antibody specifically reacting with undifferentiated liver progenitor cells., Hybridoma, pp. 0435-0439, 2009
2009 Tai CC, Chen CY, Lee HS, Wang YC, Li TK, Mersamm HJ, Ding ST, Wang PH., Docosahexaenoic acid enhances hepatic serum amyloid A expression via protein kinase A-dependent mechanism., J Biol Chem, pp. 032239-032247, 2009
2009 Chiu CC, Sheu JC, Chen CH, Lee CZ, Chiou LL, Chou SH, Huang GT, Lee HS, Global gene expression profiling reveals a key role of CD44 in hepatic oval cell reaction after 2-AAF/CCl4 injury in rodents., Histochem Cell Biol, pp. 0479-0489, 2009
2008 Sun, Y., Tan, H. Y., Lin, S. J., Lee, H. S., Lin, T. Z., Jee, S. H., Young, T. H., Wen Lo., Chen, W. L., Dong, C. Y., Imaging Tissue Engineering Scaffolds Using Multiphoton Microscopy, Microscopy Research and Technique, pp. 140-145, 2008
2008 Chou CK, Chen WL, Fwu PT, Lin SJ, Lee HS, Dong CY., Polarization ellipticity compensation in polarization second-harmonic generation microscopy without specimen rotation., J Biomed Opt., vol. 1, pp. 014005-0, 2008
2008 Hsieh CH, Lee MC, Tsai-Wu JJ, Chen MH, Lee HS, Chiang H, Herbert Wu CH, Jiang CC, Deleterious effects of MRI on chondrocytes., Osteoarthritis Cartilage, pp. 343-351, 2008
2007 Chen CH, Lee HS, Huang GT, Yang PM, Yu WY, Cheng KC, Lee PH, Jeng YM, Chen DS, Sheu JC, Phenotypic analysis of tumor-infiltrating lymphocytes in hepatocellular carcinoma., Hepatogastroenterology, pp. 1529-1533, 2007
2007 Chou HC, Chen CH, Lee HS, Lee CZ, Huang GT, Yang PM, Lee PH, Sheu JC., Alterations of tumour suppressor gene PPP2R1B in hepatocellular carcinoma., Cancer Lett, pp. 138-143, 2007
2007 Chiu CC. Huang GT, Chou SH, Chien CT, Chiou LL, Chang MH, Lee HS*, Chen DS., Characterization of cytokeratin 19-positive hepatocyte foci in the regenerating rat liver after 2-AAF/CCl4 injury., Histochem Cell Biol, pp. 217-226, 2007
2007 Su PF, Lee TC, Lin PJ, Lee PH, Jeng YM, Chen CH, Liang JD, Chiou LL, Huang GT, Lee HS*, Differential DNA methylation associated with hepatitis B virus infection in hepatocellular carcinoma, Int J Cancer, pp. 已接受-已接受, 2007
2007 Chien-Chang Chiu, Guan-Tarn Huang, Shiu-Huey Chou, Chiang-Ting Chien, Ling-Ling Chiou, Mei-Hwei Chang, Hsuan-Shu Lee, Ding-Shinn Chen, Characterization of cytokeratin 19-positive hepatocyte foci in the regenerating rat liver after 2-AAF/CCl4 injury, Histochemistry and Cell Biology, pp. 已接受-已接受, 2007
2007 Liu Y, Chen HC, Lo W, Chiou LL, Huang GT, Dong CY, Lee HS*., Visualization of hepatobiliary excretory function by intravital multiphoton microscopy, J Biomed Optics, pp. 014-014, 2007
2007 Chen CH, Yang PM, Huang GT, Lee HS, Sung JL, Sheu JC, Estimation of seroprevalence of hepatitis B virus and hepatitis C virus in Taiwan from a large-scale survey of free hepatitis screening participants, J Formos Med Assoc, pp. 148-155, 2007
2006 Lee CZ, Lee HS, Huang GT, Yang PM, Sheu JC., Detection of YMDD mutation using mutant-specific primers in chronic hepatitis B patients before and after lamivudine treatment, World J Gastroenterol, pp. 5301-5305, 2006
2006 Lee IN, Chen CH, Sheu JC, Lee HS, Huang GT, Chen DS, Yu CY, Wen CL, Lu FJ, Chow LP., Identification of complement C3a as a candidate biomarker in human chronic hepatitis C and HCV-related hepatocellular carcinoma using a proteomics approach, Proteomics, pp. 2865-2873, 2006
2006 Lee HS*, Teng SW, Chen HC, Lo W, Lin TY, Chiou LL, Jiang CC, Dong CY., Imaging human bone marrow stem cell morphogenesis in PGA scaffold by multiphoton microscopy., Tissue Eng, pp. 2835-2841, 2006
2006 Lo W, Teng SW, Tang HY, Kim KH, Chen HC, Lee HS, Chen YF, So PT, Dong CY, Intact corneal stroma visualization of GFP mouse revealed by multiphoton imaging, Microsc Res Tech, pp. 973-975, 2006
2005 Lee HS, Shun CT, Chiou LL, Chen CH, Huang GT, Sheu JC., Hydroxyproline content of needle biopsies as an objective measure of liver fibrosis: Emphasis on sampling variability., J Gastroenterol and Hepatol, pp. 1109-1114, 2005
2005 Yu HJ, Lin BR, Lee HS, Shun CT, Yang CC, Lai TY, Chien CT, Hsu SM., Sympathetic vesicovascular reflex induced by acute urinary retention evokes proinflammatory and proapoptotic injury in rat livers., Am J Physiol, pp. 1005-1014, 2005
2005 Chiang H, Kuo TF, Tsai CC, She BR, Huang YY, Lee HS, Shieh CS, Chen MH, Ramshaw J, Werkmeister J, Tuan RS, Jiang CC., Repair of porcine articular cartilage defect with autologous chondrocyte transplantation., J Orthop Res, pp. 584-593, 2005
2005 Huang YH, Chen CH, Chang TT, Chen SC, Wang SY, Lee HS, Lin PW, Huang GT, Sheu JC, Tsai HM, Lee PC, Chau GY, Lui WY, Lee SD, Wu JC., Evaluation of predictive value of CLIP, Okuda, TNM and JIS staging systems for hepatocellular carcinoma patients undergoing surgery., J Gastroenterol Hepatol, pp. 765-771, 2005
2005 Huang YH, Chen CH, Chang TT, Chen SC, Chiang JH, Lee HS, Lin PW, Huang GT, Sheu JC, Tsai HM, Lee PC, Huo TI, Lee SD, Wu JC., The role of transcatheter arterial embolization for patients with unresectable hepatocellular carcinoma: a nationwide, multicentre study evaluated by cancer stage., Aliment Pharmacol Ther, pp. 687-694, 2005
2005 Lin YW, Lee HS, Chen CH, Huang GT, Lee PH, Sheu JC., Clonality analysis of multiple hepatocellular carcinomas by loss of heterozygosity pattern determined by chromosomes 16q and 13q., J Gastroenterol Hepatol, pp. 536-546, 2005
2005 Lu JY, Chuang LM, Yang WS, Tai TY, Lai MY, Chen PJ, Kao JH, Lee CZ, Lee HS., Adiponectin levels among patients with chronic hepatitis B and C infections and in response to IFN-a therapy, Liver Int, pp. 752-759, 2005
2005 Lee HS, Sherley JL, Chen JJW, Chiu CC, Chiou LL, Liang JD, Yang PC, Huang GT, Sheu JC., EMP-1 is a junctional protein in a liver stem cell line and in the liver., Biochem Biophys Res Commun, pp. 996-1003, 2005
2005 Lee IN, Chen CH, Sheu JC, Lee HS, Huang GT, Yu CY, Lu FJ, Chow LP., Identification of Human Hepatocellular Carcinoma-Related Biomarkers by Two-Dimensional Difference Gel Electrophoresis and Mass Spectrometry., J Proteome Res, pp. 2062-2069, 2005
1989 李宣書;林肇堂(Lin, Jaw-Town);王德宏(Wang, Teh-Hong);鄧子雲(Tang, Tze-Wan);賴明陽(Lai, Ming-Yang);許金川(Sheu, Jin-Chuan);陳定信(Chen, Ding-Shinn);王正一(Wang, Cheng-Yi);陳維昭(Chen, Wei-Jao);許輝吉(Hsu, Hwei-Chi);宋瑞樓(Sung, Juei-Low), Clinical Study of Cholangiocarcinomapp, Chinese Journal of Gastroenterology, pp. 101-111, 1989