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退休教師
專任教師
合聘、兼任教師
退休教師
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職稱
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宋麗英
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886-2-3366-6015~16
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liyingsung@ntu.edu.tw
研究專長
胚胎學 / 核再程序化 / 胚幹細胞 / 生殖科技
著作發表
實驗室成員
年度
論文名稱
2024
Chia-Jung Li, Chia-Chun Chang, Li-Kuang Tsai, Min Peng, Wei-Ni Lyu, Jane-Fang Yu, Mong-Hsun Tsai, Li-Ying Sung, Generation of induced pluripotent stem cells from Bornean orangutans, Front Cell Dev Biol., vol. 5, 11, Jan. 2024
2023
Tsai, LK., Peng, M., Chang, CC., Wen, L., Liu, L., Liang, X., Chen, Y. E., Xu, J., Sung, LY., ZSCAN4 interacts with PARP1 to promote DNA repair in mouse embryonic stem cells, Cell Biosci., vol. 13, 1, pp. 193-193, Oct. 2023
2022
Chang, WF., Lin, TY., Peng, M., Chang, CC., Xu, J. Hsieh-Li, HM., Liu, JL., Sung, LY., Survival Motor Neuron Enhances Pluripotent Gene Expression and Facilitates Cell Reprogramming, Stem Cells Dev., vol. 31, 21-22, pp. 696-705, Nov. 2022
2022
Tsai, LK., Ou-Yang, H., Xu, J., Chen, CM., Chang WF., Sung, LY., Effects of Recloning on the Telomere Lengths of Mouse Terc+/- Nuclear Transfer-Derived Embryonic Stem Cells, Stem Cells Dev., vol. 31, 21-22, pp. 720-729, Nov. 2022
2022
Chen, W. J., Huang, W. K., Pather, S. R., Chang, W. F., Sung, L. Y., Wu, H. C., Liao, M. Y., Lee, C. C., Wu, H. H., Wu, C. Y., Liao, K. S., Lin, C. Y., Yang, S. C., Lin, H., Lai, P. L., Ng, C. H., Hu, C. M., Chen, I. C., Chuang, C. H., Lai, C. Y., Lin, P. Y., Lee, Y. C., Schuyler, S. C., Schambach, A., Lu, F. L., Lu, J.
, Podocalyxin-Like Protein 1 Regulates Pluripotency through the Cholesterol Biosynthesis Pathway, Adv Sci (Weinh)., vol. 10, 1, Nov. 2022
2022
Chang, CC., Peng, M., Zhong, J., Zhang, Z., Keppeke, GD., Sung, LY., Liu, JL., Molecular crowding facilitates bundling of IMPDH polymers and cytoophidium formation, Cell Mol Life Sci., vol. 79, 8, Jul. 2022
2021
Ou-Yang H, Wu SC, Sung LY, Yang SH, Yang SH, Chong KY, Chen CM, STAT3 Is an Upstream Regulator of Granzyme G in the Maternal-To-Zygotic Transition of Mouse Embryos, International Journal of Molecular Sciences, vol. 22(1):460, 2021
2021
Chang WF, Peng M, Hsu J, Xu J, Cho HC, Hsieh-Li HM, Liu JL, Lu CH*, Sung LY*, Effects of Survival Motor Neuron Protein on Germ Cell Development in Mouse and Human, International Journal of Molecular Sciences, vol. 22(2):661, 2021
2020
Chang WF, Xu J, Lin TY, Hsu J, Hsieh-Li HM, Hwu YM, Liu JL, Lu CH, Sung LY*, Survival Motor Neuron Protein Participates in Mouse Germ Cell Development and Spermatogonium Maintenance, International Journal of Molecular Sciences , vol. 21(3):794, 2020
2020
Chakraborty A, Lin WC, Lin YT, Huang KJ, Wang PY, Chang IY, Wang HI, Ma KT, Wang CY, Huang XR, Lee YH, Chen BC, Hsieh YJ, Chien KY, Lin TY, Liu JL, Sung LY, Yu JS, Chang YS, Pai LM, SNAP29 mediates the assembly of histidine-induced CTP synthase filaments in proximity to the cytokeratin network, Journal of Cell Science, vol. 133(9):jcs240200, 2020
2019
Chang WF, Wu YH, Xu J, Sung LY*. , Compromised Chondrocyte Differentiation Capacity in TERC Knockout Mouse Embryonic Stem Cells Derived by Somatic Cell Nuclear Transfer., International Journal of Molecular Sciences, vol. 20(5), Mar. 2019
2018
Chang CC, Keppeke GD, Sung LY*, Liu JL*, Inter-filament interaction between IMPDH and CTPS cytoophidia, FEBS Journal, vol. 285, 20, pp. 3753-3768, Oct. 2018
2018
Lin WC, Chakraborty A, Huang SC, Wang PY, Hsieh YJ, Chien KY, Lee YH, Chang CC, Tang HY, Lin YT, Tung CS, Luo JD, Chen TW, Lin TY, Cheng ML, Chen YT, Yeh CT, Liu JL, Sung LY, Shiao MS, Yu JS, Chang YS, Pai LM*., Histidine-Dependent Protein Methylation Is Required for Compartmentalization of CTP Synthase., Cell Reports, vol. 24, 10, pp. 2733-2745, Sep. 2018
2018
Keppeke GD, Chang CC, Peng M, Chen LY, Lin WC, Pai LM, Andrade LEC, Sung LY*, Liu JL*, IMP/GTP balance modulates cytoophidium assembly and IMPDH activity, Cell Div, vol. 13:5, Jun. 2018
2017
Chang CC, Jeng YM, Peng M, Keppeke GD, Sung LY*, Liu JL*, CTP synthase forms the cytoophidium in human hepatocellular carcinoma, Experimental Cell Research, vol. S0014-4827(17)30576-1, Oct. 2017
2017
Wu FJ, Lin TY, Sung LY, Chang WF, Wu PC, Luo CW. , BMP8A sustains spermatogenesis by activating both SMAD1/5/8 and SMAD2/3 in spermatogonia, Sci Signal.(Cover story), vol. 10(477)., eaal1910, May. 2017
2016
Chang WF, Hwu YM, Xu J, Lin CJ, Wang SW, Cheng AS, Lu J, Lu CH, Sung LY*., Derivation of Patient Specific Pluripotent Stem Cells Using Clinically Discarded Cumulus Cells, PLoS ONE , vol. 1, 11, pp. e0165715-, Nov. 2016
2016
Chang CC, Chang WF, Xu J, Cheng AS, Chang CC, Nagy ZP, Yang CC, Ding ST, Sung LY*, Production of Live Offspring from Vitrified-Warmed Oocytes Collected at Metaphase I Stage, PLoS ONE, vol. 11, 6, pp. e0157785-, Jun. 2016
2016
Liu CC, Chang TC, Lin YT, Yu YL, Ko BS, Sung LY*, Liou JY*. , Paracrine Regulation of Matrix Metalloproteinases Contributes to Cancer Cell Invasion by Hepatocellular Carcinoma Secreted 14-3-3σ, Oncotarget, vol. doi: 10.18632/oncotarget.9234, May. 2016
2015
Chang CC, Lin WC, Pai LM, Lee HS, Wu SC, Ding ST, Liu JL*, Sung LY*. (*Corresponding authors), Cytoophidium assembly reflects upregulation of IMPDH activity., Journal of Cell Science (Cover photo), vol. pii: jcs.175265. [Epub ahead of print], Aug. 2015
2015
Cheng YT, Yeih DF, Liang SM, Chien CY, Yu YL, Ko BS, Jan YJ, Kuo CC, Sung LY, Shyue SK, Chen MF, Yet SF, Wu KK, Liou JY., Rho-associated kinase inhibitors promote the cardiac differentiation of embryonic and induced pluripotent stem cells., Int J Cardiol, vol. 201, pp. 441-448, Aug. 2015
2015
Liao HF, Mo CF, Wu SC, Cheng DH, Yu CY, Chang KW, Kao TH, Lu CW, Pinskaya M, Morillon A, Lin SS, Cheng WT, Bourc'his D, Bestor T, Sung LY, Lin SP., Dnmt3l-knockout donor cells improve somatic cell nuclear transfer reprogramming efficiency., Reproduction, vol. 150(4), pp. 245-256, Jul. 2015
2014
Sung LY, Chang WF, Zhang Q, Liu CC, Liou JY, Chang CC, Ou-Yang H, Guo R, Fu H, Cheng WT, Ding ST, Chen CM, Okuka M, Keefe DL, Chen YE, Liu L*, Xu J*., Telomere elongation and naïve pluripotent stem cells achieved from telomerase haplo-insufficient cells by somatic cell nuclear transfer, Cell Reports , vol. 9, 5, pp. 1603-1609, Dec. 2014
2014
Aughey GN*, Grice SJ*, Shen QJ*, Xu Y, Chang CC, Azzam G, Wang PY, Freeman-Mills M, Pai LM, Sung LY, Yan J and Liu JL. , Nucleotide synthesis is regulated by cytoophidium formation during neurodevelopment and adaptive metabolism, Biology Open, vol. pii: BIO201410165, [Epub ahead of print], Oct. 2014
2014
Liu CC, Jan YJ, Ko BS, Wu YM, Liang SM, Chen SC, Lee YM, Liu TA, Chang TC, Wang J, Shyue SK, Sung LY*, Liou JY*. (*Corresponding authors)., 14-3-3σ induces heat shock protein 70 expression in hepatocellular carcinoma, BMC Cancer, vol. 14, 1, pp. 425-436, Jun. 2014
2014
Gou KM*, Chang CC*, Shen QJ, Sung LY** and Liu JL**. (*These authors contributed equally to this work; **Corresponding authors)., CTP synthase forms cytoophidia in the cytoplasm and nucleus, Experimental Cell Research , vol. 323, (1), pp. 242-253, Apr. 2014
2014
Chang WF, Xu J, Chang CC, Yang SH, Li HY, Hsieh-Li HM, Tsai MH, Wu SC, Cheng WTK, Liu JL* and Sung LY*. (*Corresponding authors)., SMN is required for the maintenance of embryonic stem cells and neuronal differentiation in mice, Brain Structure & Function, vol. [Epub ahead of print], Mar. 2014
2013
Chen, F. Du, J. Xu, W.F. Chang, C.C. Liu, H.Y. Su, T.A. Lin, J.C. Ju, W.T.K. Cheng, S.C. Wu, Y.E. Chen, L.Y. Sung* (*通訊作者) , Synergistic Effect of Trichostatin A and Scriptaid on the Development of Cloned Rabbit Embryos. , Theriogenology, vol. 79, pp. 1284-1293, Apr. 2013
2012
Chen CH., Chang WF., Liu CC., Su HY., Shyue SK., Cheng W. TK., Y. Chen E., Wu SC., Du F., Sung LY.*, Jie Xu*. Spatial and Temporal Distribution of Oct-4 Expression and H4K5 Acetylation in Rabbit Embryos. Reproductive BioMedicine Online. 2012 Apr;24(4):433-42. (SCI, *通訊作者) , 2012
2012
Chen CH, Xu J, Chang WF, Liu CC, Su HY, Eugene Chen Y, Du F, Sung LY*. Dynamic profiles of Oct-4, Cdx-2 and acetylated H4K5 in in-vivo-derived rabbit embryos. Reproductive BioMedicine Online. 2012 Oct;25(4):358-70. (SCI, *通訊作者) , 2012
2012
Li Y, Pal R, Sung LY, Feng H, Miao W, Cheng SY, Tian C, Cheng T. An Opposite Effect of the CDK Inhibitor, p18(INK4c) on Embryonic Stem Cells Compared with Tumor and Adult Stem Cells. PLoS ONE. 2012;7(9):e45212. (SCI) , 2012
2012
Chang TC, Liu CC, Hsing EW, Liang SM, Chi YH, Sung LY, Lin SP, Shen TL, Ko BS, Yen BL, Yet SF, Wu KK, Liou JY. 14-3-3s Regulates b-Catenin-Mediated Mouse Embryonic Stem Cell Proliferation by Sequestering GSK-3b. PLoS ONE. 2012;7(6):e40193. (SCI) , 2012
2011
Sung LY, Chen CH, Xu J, Lin TA, Su HY, Chang WF, Liu CC, Sung YS, Cheng WTK, Zhang J, X. C. Tian, Ju JC, Chen TE, Wu SC, Du F. Follicular oocytes better support development in rabbit cloning than oviductal oocytes. Cellular Reprogramming. 2011 Dec;13(6):503-12. Epub 2011 Oct 26. (SCI) , 2011
2010
Chang CC, Sung LY, Lin CJ, Kort HI, Yang X, Tian XC, Nagy ZP. The oocyte spindle is preserved by 1,2-propanediol during slow freezing. Fertil Steril. 2010 Mar 15;93(5):1430-9. (SCI), 2010
2010
Chang CC, Gao S, Sung LY, Corry GN, Ma Y, Nagy ZP, Tian XC, Rasmussen TP. Rapid elimination of the histone variant MacroH2A from somatic cell heterochromatin after nuclear transfer. Cell Reprogram. 2010 Feb;12(1):43-53. (SCI) , 2010
2010
Lin TA, Chen CH, Sung LY, Carter MG, Chen YE, Du F, Ju JC, Xu J. Open-pulled straw vitrification differentiates cryotolerance of in vitro cultured rabbit embryos at the eight-cell stage. Theriogenology. 2010 Dec 6. [Epub ahead of print]. (SCI), 2010
2010
Chang CC, Lin CJ, Sung LY, Kort HI, Tian XC, Nagy ZP. Impact of phase transition on the mouse oocyte spindle during vitrification. Reprod Biomed Online. 2010 Oct 31. [Epub ahead of print] (SCI), 2010
2010
Sung LY., Chang CC, Amano T, Lin CJ, Amano M, Treaster SB, Xu J, Chang WF, Nagy ZP, Yang X, Tian XC. Efficient derivation of embryonic stem cells from nuclear transfer and parthenogenetic embryos derived from cryopreserved oocytes. Cellular Reprogramming. 2010 Apr;12(2):203-11. (SCI) , 2010
2009
Smith, S.L., Everts, R.E., Sung, L-Y., Du, F., Page, R.L., Henderson, B., Rodriguez-Zas, S.L., Nedambale, T.L., Renard, J.P., Lewin, H.A., Yang, X., Tian, X.C. Gene Expression Profiling of Single Bovine Embryos Uncovers Significant Effects of In Vitro Maturation, Fertilization and Culture. Mol. Reprod. Dev., 2009 Jan;76(1):38-47. (SCI), 2009
2009
Du F., Xu J., Zhang J., Gao S., Carter MG., He C., Sung LY., Chaubal S., Fissore R. A., Tian XC., Yang X. and Chen YE. Beneficial Effect of Young Oocytes for Rabbit Somatic Cell Nuclear Transfer. Cloning and Stem Cells. 2009 Mar;11(1):131-40. (SCI), 2009
2009
Amano, T., Papanikolaou, T., Sung, L-Y., Conover, J., and Yang, X. Nuclear Transfer Embryonic Stem Cells Provide an In Vitro Culture Model for Parkinson's Disease. Cloning Stem Cells. 2009 Mar;11(1):77-88. (SCI), 2009
2009
Suteevun-Phermthai T, Curchoe CL, Evans AC, Boland E, Rizos D, Fair T, Duffy P, Sung LY, Du F, Chaubal S, Xu J, Wechayant T, Yang X, Lonergan P, Parnpai R, Tian XC. Allelic switching of the imprinted IGF2R gene in cloned bovine fetuses and calves. Anim Reprod Sci. 2009 Nov;116(1-2):19-27. (SCI), 2009
2009
Chang CC., Sung LY., Amano T., Tian XC., Yang X., Nagy ZP. Nuclear transfer and oocyte cryopreservation. Reproduction, Fertility and Development, 2009;21(1):37-44. (SCI), 2009
2007
Yang, X., Cheng, T., Sung, L-Y,. Gao, S., Shen, H., Yu, H., Song, Y., Smith, S.L., Tuck, D.P., Inoue, K., Weissman, S.M. Reply to "On the cloning of animals from terminally differentiated cells". Nature Genetics, 2007 Feb; 39(2):137-8. (SCI), 2007
2007
Sung, L-Y., Shen, P-C., Jeong, BS., Xu, J., Chang, C-C., Cheng, WTK., Wu, J-S., Lee, S-N., Broek, D., Faber, D., Tian, XC., Yang, X., Du, F. Premature Chromosome Condensation Is Not Essential for Nuclear Reprogramming in Bovine Somatic Cell Nuclear Transfer. Biol Reprod., 2007 Feb; 76(2):232-40. (SCI) , 2007
2007
Lonergan P, Evans AC, Boland E, Rizos D, Fair T, Duffy P, Sung LY, Du F, Chaubal S, Xu J, Yang X, Tian XC. Pregnancy and fetal characteristics after transfer of vitrified in vivo and cloned bovine embryos. Theriogenology. 2007 Nov;68(8):1128-37. (SCI), 2007
2007
Tian, X.C., Smith, S.L., Zhang, S.Q., Kubota, C., Curchoe, C., Xue, F., Yang, L., Du, F., Sung, L-Y., Yang, X. Nuclear reprogramming by somatic cell nuclear transfer – the cattle story. Soc Reprod Fertil Suppl. 2007;64:327-39. Review., 2007
2006
Du, F., Shen, P.C., Xu, J., Sung, L-Y., Jeong, BS., Nedambale, L.T., Riesen, J., Tian, C.X., Cheng, W.T.K., Lee, S.N., Yang, X. The cell agglutination agent, phytohemagglutinin-L, improves the efficiency of somatic nuclear transfer cloning in cattle (Bos taurus). Theriogenology, 2006, 65(3): 642-57. (SCI), 2006
2006
Sung, L-Y. Gao, S., Shen, H., Yu, H., Song, Y., Smith, S.L., Chang, C-C., Inoue, K., Kuo, K., Lian, J., Li, A., Tian, X.C., Tuck, D.P., Weissman, S.M., Cheng, T., Yang, X. Differentiated cells are more efficient than adult stem cells for cloning by somatic cell nuclear transfer. Nature Genetics, 2006 Nov; 38(11): 1323-8. (SCI), 2006
2005
Wang, L., Duan, E., Sung, L-Y., Jeong, B-S., Yang, X., and Tian, CT. Generation and Characterization of Pluripotent Stem Cells from Cloned Bovine Embryos. Biol Reprod., 2005, 73: 149 – 155. (SCI), 2005
2005
Enright, B.P., Sung, L-Y., Chang, C.C., Yang, X., Tian, X.C. Methylation and Acetylation Characteristics of Cloned Bovine Embryos from Donor Cells Treated with 5-aza-2'-deoxycytidine. Biol Reprod., 2005, 72: 944-948. (SCI), 2005
2005
Smith, S.L., Everts, R.E., Tian, X.C., Du, F., Sung, L-Y., Rodriguez-Zas, S.L., Jeong, B.S., Renard, J.P., Lewin, H.A., Yang, X. Global gene expression profiles reveal significant nuclear reprogramming by the blastocyst stage after cloning. Proc Natl Acad Sci U S A. 2005, 102(49): 17582-7. (SCI), 2005
2004
Liu, J-L., Sung, L-Y., Du, F., Julian, M., Jiang, S., Barber, M., Xu, J., Tian, X. C. and Yang, X. Differential development of rabbit embryos derived from parthenogenesis and nuclear transfer. Mol. Reprod. Dev., 2004, 68:58-64. (SCI), 2004
2004
Sung, L-Y., Du, F., Xu, J., Chang, W., Jiang, S., Tian, X.C. and Yang, X. The effect of albumin and sodium citrate on the development of in vitro produced bovine embryos under different oxygen tension. Reprod Nutri Dev., 2004, 44:551-564. (SCI) , 2004
2002
Du, F., Sung, L-Y., Tian, X. C. and Yang, X. Differential cytoplast requirement for embryonic and somatic cell nuclear transfer in cattle. Mol. Reprod. Dev., 2002, 63:183-191. (SCI), 2002
2002
Liu, J-L., Sung, L-Y., Tian, X. C. and Yang, X. Hypertonicity-Induced Projections Reflect Cell Polarity in Mouse Metaphase II Oocytes: Involvement of Microtubules, Microfilaments, and Chromosomes. Biol Reprod., 2002, 67: 1853 - 1863. (SCI), 2002
2002
Liu, J-L., Sung, L-Y., Barber, M., and Yang, X. Hypertonic Medium Treatment for Localization of Nuclear Material in Bovine Metaphase II Oocytes. Biol Reprod., 2002, 66: 1342 - 1349. (SCI), 2002
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