NTU Bio-Tech

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Introduction

This institute has been established in August 2006 and began to enroll PhD students since that academic year. The mission of this institute is to provide great research and teaching environment for the following fields that match the directions of our national policies: bioinformatics, nano-biomedical research, tissue engineering and regenerative medicine, genomics and proteomics. 
Year 2022
Authors Chi-Te LIU
Vol.No 23:602
Level Type SCI
Date of Publication 2022-08-19
Abstract It is currently assumed that around 100 million years ago, the common ancestor to the Fabales, Fagales, Rosales and
Cucurbitales in Gondwana, developed a root nodule symbiosis with a nitrogen-fxing bacterium. The symbiotic trait
evolved frst in Frankia cluster-2; thus, strains belonging to this cluster are the best extant representatives of this origi‑
nal symbiont. Most cluster-2 strains could not be cultured to date, except for Frankia coriariae, and therefore many
aspects of the symbiosis are still elusive. Based on phylogenetics of cluster-2 metagenome-assembled genomes
(MAGs), it has been shown that the genomes of strains originating in Eurasia are highly conserved. These MAGs are
more closely related to Frankia cluster-2 in North America than to the single genome available thus far from the
southern hemisphere, i.e., from Papua New Guinea.
To unravel more biodiversity within Frankia cluster-2 and predict routes of dispersal from Gondwana, we sequenced
and analysed the MAGs of Frankia cluster-2 from Coriaria japonica and Coriaria intermedia growing in Japan, Taiwan
and the Philippines. Phylogenetic analyses indicate there is a clear split within Frankia cluster-2, separating a continen‑
tal from an island lineage. Presumably, these lineages already diverged in Gondwana.
Based on fossil data on the host plants, we propose that these two lineages dispersed via at least two routes. While
the continental lineage reached Eurasia together with their host plants via the Indian subcontinent, the island lineage
spread towards Japan with an unknown host plant.
Language Chinese
Reference URL https://doi.org/10.1186/s12864-022-08838-5
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