NTU Bio-Tech

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Introduction

This institute has been established in August 2006 and began to enroll PhD students since that academic year. The mission of this institute is to provide great research and teaching environment for the following fields that match the directions of our national policies: bioinformatics, nano-biomedical research, tissue engineering and regenerative medicine, genomics and proteomics. 

Implication of Logo

DNA is at the center of life. Many studies on life science or development in biotechnology depend largely on unraveling it. Genomic approach thus forms the intersection core among the 3 fields of plant, animal, and microbial biotech in this institute. The microbe in the leaf indicates plant-microbe interactions. The woman head represents the animal and medical fields. The boxes are symbolic for microarray results and represent the bioinformatics. These symbols linked together indicate cross-disciplinary researches that are flourishingly developing in this institute.

Interview of Assistant Professor, Dr. Shu-Han, Yu

Today we interviewed our new faculty, Dr. Shu-Han Yu, who has immuno-oncology, immune modulation, tumor microenvironment, and microbiome professional with 9+ years of academic research experience and 4+ years of industrial experience. She has committed to transforming expertise in translational medicine into non-small-cell lung cancer precision medicine, microbiome profiling, biomarker discovery, characterization, clinical validation, and potential diagnostics.

Interview of Director, Professor Mong-Hsun Tsai

Today we are very happy to interview the new director of Institute of Biotechnology (IOB), Prof. Mong-Hsun Tsai, to talk about his research journey. Graduated from the Department of Zoology at National Taiwan University (NTU), Prof. Tsai has established solid biology backgrounds. Prof. Tsai then decided to proceed his master at National Tsing Hua University (NTHU). His study mainly focused on radiation and heavy metal (such as arsenic) induced damages in molecular, cellular, and phenotype levels. For Dr. Tsai’s dissertation at National Yang Ming University, he mainly studied health effects of chronic low-dose radiation exposed subjects who lived in Co60-contaminated buildings for more than 10 years in Taiwan. Dr. Tsai stayed in NIH for 4 years and came back to NTU as an assistant professor in 1996. Prof. Tsai has been employing biochips and bioinformatics tools for agriculture applications and to discover specific biomarkers for cancer outcome prediction. 

Interview of Professor Jen-Chih Chen

Our interviewee today is Prof Jen-Chih Chen, driving by his curiosity, he is now an associate professor in the Institute of Biotechnology (IOB), and his research expertise includes plant defense, molecular biology, as well as bioenergy.

From the interview, we can feel that Dr. Chen is full of curiosity. He is interested in all sorts of biological phenomena, and enjoys dissecting them. He may have changed his research focus to animal studies, but through searching and experiencing, he returned to his beloved plant science. He told us to keep on trying new things and new ways, and by doing so, we may be able to find something really surprising. Of course, there are always challenges, and keeping on trying and enriching your knowledge should carry you a long way during your research.

Interview of Professor Chi-Te Liu

Today we invite Dr. Chi-Te Liu, an associate professor of the Institute of Biotechnology (IOB), to share his journey of research and development. Dr. Liu’s research interests focus on S.E.A, i.e. Symbiosis (Microbe-Plant interactions), Environmental microbiology, and Agricultural biotechnology. The current projects in his lab including (1) development of multifunctional PGPR agents (biofertilizers & biopesticides), (2) exploring the molecular mechanisms of plant-microbe interactions, (3) biodegradation of synthetic plastics, and (4) employing soil-based microbial batteries for sustainable agriculture and energy.Today we invite Dr. Chi-Te Liu, an associate professor of the Institute of Biotechnology (IOB), to share his journey of research and development. Dr. Liu’s research interests focus on S.E.A, i.e. Symbiosis (Microbe-Plant interactions), Environmental microbiology, and Agricultural biotechnology. The current projects in his lab including (1) development of multifunctional PGPR agents (biofertilizers & biopesticides), (2) exploring the molecular mechanisms of plant-microbe interactions, (3) biodegradation of synthetic plastics, and (4) employing soil-based microbial batteries for sustainable agriculture and energy.

Interview of Professor Je-Ruei Liu

Today we invite Dr. Je-Ruei Liu, professor of the Institute of Biotechnology (IOB) and vice dean of College of Bio-Resources and Agriculture, to share his journey of research. With the fast-pace of modern lifestyle, dietary habits are characterized by erratic eating patterns . Malnutrition, unhealthy diet, smoking, stress and so on, are the presentations of unhealthy life lifestyle. Unwanted diseases and afflictions arise from such dietary habits. Obesity is on the rise and has become a chronic problem, along with aging, diabetes, as well as high blood pressure. Another issue in the modern lifestyle is the declining birth rate. More and more people choose to have pets. Yet the number of overweight and obese in our furry family members also is a growing concern. Professor Je-Ruei Liu has been engaged in research on obesity related topics for many years, hoping to apply natural products to delay aging, to reduce pet weight, and to promote healthier diets for our pets.
 

Interview of Professor Li-Ying, Sung

Professor Sung is an expert in SCNT and among the first to report cloned mice using terminally differentiated postmitotic granulocytes, followed by efficient derivation of mouse ntESCs. Her team also cloned cattle and rabbits before.  She excels in embryonic technologies, such as SCNT, pronuclear microinjection, intracytoplasmic sperm injection, blastocyst injection, oocyte and embryo cryopreservation, as well as iPSC technology. Her research interests are embryology, developmental biology, stem cell biology, as well as development of novel animal models to study human diseases including infertility. She is also applying these modern tools to save endangered animals.

Interview of Professor Kuan-Chen Cheng

Being a professor in both Institute of Biotechnology (IOB) and Institute of Food Sciences and
Technology (FST) at National Taiwan University, Prof Cheng proofs his doubtlessly research
experiences in the areas of microbial bioprocessing, fermentation and biotechnology. His
laboratory currently focusing on four major topics which are bioactivity of medical mushroom,
Wine making and brewing, Development of Senior’s Food, and Biotechnology.

Interview of Professor Shih-Shun Lin

Birds migrate south for winter. Fishes swim to their ideal water current. Unlike animals, plants are not able to move freely forces the plants to adapt to the environment. It is a pleasure to invite Prof. Shih-Shun Lin from the Laboratory of Plant Molecular Biology and Virology to talk about gene regulation mechanisms that help the plants to survive from environmental adversity and disease invasion.
 
 

Personal Project

Project Category Year Project Title Participator Job Title Period Unit
2013 幹細胞命運決定因子之探討與應用-藉由層黏連蛋白修飾的褐藻膠支架與肝臟轉錄調控因子以提高間葉幹細胞的藥物代謝活性之分子機制探討(1/2) 李宣書 主持人 2013.08 ~ 2014.07 科技部
2013 PiRNA 調節網絡對於雞胚生殖細胞發育之重要性 林劭品 2013.07 ~ 2014.08 NSC
2013 發展活體共焦顯微術以研究小鼠Indocyanine Green (ICG) 肝膽代謝機制Development of Intravital Confocal Fluorescence Microscopy for Studying Hepatobiliary Metabolism of Indocyanine Green (ICG) in Mouse 李宣書 主持人 2013.01 ~ 2013.12 台大醫院與台灣大學各學院合作研究計畫
2012 類3號DNA甲基化酶相關之反轉錄病毒抑制機制 林劭品 主持人 2012.08 ~ 2013.07 NSC
2012 演化過程中基因體完整性之維持:探究生殖細胞如何在跳躍子之威脅下征戰得勝 林劭品 主持人 2012.08 ~ 2013.07 NTU
2012 觀測動態影像及量化肝癌對肝臟代謝與功能的影響(1/3) 李宣書 共同計畫主持人 2012.08 ~ 2013.07 科技部
2012 再程序化細胞治療應用於肝臟再生的分子及細胞學研究-以無病毒及無載體之方法製造人類引導式肝細胞來進行肝臟再生研究Production of virus- and vector-free human induced hepatocytes for liver regeneration 李宣書 主持人 2012.08 ~ 2013.07 國科會
2012 墨西哥蠑螈之再生芽基細胞血統追蹤與鑑定(3/3)Lineage tracing and characterization of blastema cells from Ambystoma mexicanum 李宣書 主持人 2012.08 ~ 2013.07 國科會
2012 利用高通量定序分析技術及奈米場效電晶體偵測技術探討B型肝炎病毒於細胞內small RNAs的變化導致肝硬化及肝癌之相關性研究 李宣書 主持人 2012.01 ~ 2012.12 台大醫院與台灣大學各學院合作研究計畫
2012 利用拉曼光譜偵測與肝細胞直接共同培養的間葉系幹細胞的肝細胞分化程度 李宣書 主持人 2012.01 ~ 2012.12 臺大醫院暨台北榮總兩院合作研究